do you
speak
brca?
Learn more about the 23andMe
BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report
here.
Have a personal or family history of cancer? Talk to your healthcare provider to determine if comprehensive genetic testing is appropriate.
BRCA EDUCATION
Let's begin at the very beginning.
BRCA stands for BReast CAncer gene. You can pronounce it "brah-kuh" or you can say "B" "R" "C" "A". When we talk about BRCA1 and BRCA2, we are speaking the language of human genetics. We are speaking BRCA.
You can, too.
BRCA EDUCATION
Want to learn to speak BRCA?
Here are some terms to know.
Here are some terms to know.
Speaking BRCA won't require you to master any verb conjugations, but there are several important genetic terms you may want to know. Here are five of the most important:
BRCA GENE EDUCATION
BRCA Basics
BRCA1 and BRCA2 are genes that have been found to impact a person's chances of developing certain cancers, including breast, ovarian and prostate cancer.
What It Means:
The genes are called BRCA because the link between these genes and breast cancer was discovered first. The genes themselves do not cause cancer. They actually help prevent it by repairing DNA breaks that can lead to cancer. This is why we refer to them as tumor suppressor genes.
Sometimes, changes in the BRCA genes occur that prevent them from functioning properly. These changes are called genetic variants or mutations. Variants in the BRCA1 and BRCA2 genes can be passed down through families, increasing the risk of developing certain cancers. This is what was referenced in our glossary as hereditary risk.
Why It Matters:
Knowledge is empowerment. Many people with a BRCA variant, both women and men, are unaware of their risk and what they can do about it. While it is true that having certain BRCA variants can increase a person's risk of developing cancer, most cases of breast, ovarian and prostate cancers aren't caused by inherited BRCA variants. And not every individual who inherits a BRCA variant will develop cancer.
BRCA EDUCATION
The BRCA Story:
Three Decades of
Discovery.
1
Three Decades of Discovery. 1
There's a reason you may have never heard of BRCA1 and BRCA2. Prior to their identification by researchers nearly 30 years ago, nobody had. Here are a few of the key milestones.
ABOUT THE REPORT
Let's be clear.
(Let's be frank, too.)
(Let's be frank, too.)
23andMe's BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report is many things – direct-to-consumer, FDA-authorized – but there are many things it isn't. Why emphasize what we aren't? Because here's what we are – committed to transparency. We are absolutely dedicated to guiding you through the landscape of BRCA, regardless of whether or not you choose to access this report through 23andMe's Health + Ancestry Service. For customers who choose to view their results, we will provide you with information about important considerations regarding how to read and use the report.
ABOUT THE REPORT
The BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report is not a comprehensive cancer screening test.
ABOUT THE REPORT
Specific BRCA genetic variants are more common in certain populations.
ABOUT THE REPORT
Most cases of breast cancer, ovarian cancer and prostate cancer are not caused by inherited BRCA variants.
Other factors also play
an important role.-
Known variants in other genes
that affect cancer risk -
Unknown genetic factors
that may affect cancer risk -
Other factors such as lifestyle,
environment and family history
The experiences of our customers are a true testament to the value of understanding your genetics.*
Helpful BRCA Resources
(We have them.)
At 23andMe, we are committed to helping you understand what a BRCA result means and describing important limitations of the report. There are also many trusted advocacy organizations who share our commitment to the BRCA community and provide a wide array of educational and support services. We encourage you to reach out to these organizations to deepen your knowledge and empower yourself.
Still have questions?
You're not the only one.
Cancer is a complex disease: The experts still have questions. Here are just a few of the questions "non-experts" have been asking about 23andMe's BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report. We encourage you to talk with a healthcare professional, such as a genetic counselor, to get the answers you need.
Our BRCA test for the three variants we detect meets FDA requirements for analytical, clinical and scientific validity. As with our other FDA-reviewed reports, each variant we report demonstrated greater than 99 percent agreement with an accepted comparison method. It also showed greater than 99 percent reproducibility and repeatability. Keep in mind that because this is an at-home test it is important to confirm results in a clinical setting before taking any medical action. Learn more.
You did it.
If you have read this far, you have achieved a basic level of BRCA proficiency. We knew you could do it! The question is, what will you do with it? Talk to your healthcare provider? Share what you've learned with a friend or family member? We encourage you to do both.
Live in the know. SMLearn more about our Health + Ancestry Service.
1 1990: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191015/ 1994: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191015/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360226/ 1996: https://www.nature.com/articles/gim200320 2013: http://www.bmj.com/content/355/bmj.i6357
2 https://jmg.bmj.com/content/47/10/710.long , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267289/ , https://surveillance.cancer.gov/statistics/types/lifetime_risk.html
*The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of 44 variants in the BRCA1 and BRCA2 genes. The report describes if a person's genetic result is associated with an increased risk of developing breast cancer and ovarian cancer and may be associated with an increased risk for prostate cancer, pancreatic cancer, and potentially other cancers. The variants included in this report do not represent the majority of the BRCA1/BRCA2 variants in people of most ethnicities. This report does not include variants in other genes linked to hereditary cancers and the absence of variants included in this report does not rule out the presence of other genetic variants that may impact cancer risk. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed in a clinical setting before taking any medical action.